Effects of Kudzu Root on Oxidative Stress and Inflammation in Streptozotocin-induced Diabetic Rats
Publish place: Iranian Journal of Veterinary Medicine، Vol: 17، Issue: 4
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJVM-17-4_012
تاریخ نمایه سازی: 13 مهر 1402
Abstract:
Background: Oxidative stress and inflammation are strictly connected, and both perform an important role in the pathogenesis of diabetes mellitus (DM).Objectives: This research aimed to investigate the potential protective effect of kudzu root against oxidative stress and inflammation in a streptozotocin (STZ)-induced DM animal model.Methods: DM was induced in male Wistar rats by intraperitoneal injection of STZ (۵۰ mg/kg body weight). The kudzu root (۱۰۰ mg/kg BW) was administered orally after ۱ week of STZ administration in diabetic animals (for ۶ weeks).Results: The diabetic animals exhibited a significant increase in fasting blood glucose, tumor necrosis factor-alpha, and malondialdehyde levels. However, they exhibited a significant decrease in plasma insulin level, superoxide dismutase, and glutathione peroxidase activity. Administration of kudzu root to diabetic animals reversed these effects.Conclusion: The current study indicated that kudzu root has potent antidiabetic properties, likely through its anti-inflammatory and anti-oxidative properties in the STZ-diabetic rat model.
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Authors
Monireh Shahsavari
Khatamolanbia Hospital, Islamic Azad University, Shahroud Branch, Shahroud, Iran.
Pirasteh Norouzi
Department of Physiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Hamid Kalalianmoghaddam
Department of Physiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Maryam Teimouri
Department of Clinical Biochemistry, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran.
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