Effect of Vitamin E on Blood Glucose, Lipid Profile and Blood Pressure in Type ۲ Diabetic Patients

OBJECTIVE: Type ۲ diabetes is associated with elevated oxidative stress and decline in antioxidant defense. Vitamin E supplementation reduces oxidative stress level in diabetic pa-tients. Purpose of this study was to evaluate the effect of vitamin E supplementation on glycemic control and lipid profile in type ۲ diabetic patients. MATERIAL AND METHODS: In this study ۳۱ type ۲ diabetic patients with Fasting blood Sugar (FBS):۱۴۰-۲۰۰ mg/dl, Triglyceride (TG): ۲۰۰-۴۰۰ mg/dl, Cholesterol (TC): ۲۰۰-۳۰۰ mg/dl and mild hypertension were selected. Subjects received vitamin E ۸۰۰ IU/day for ۳ months. At the baseline and end of the study FBS, TC, TG, LDL, HDL, Glycated hemoglobin and fasting insulin level were measured. RESULTS: In this study ۳۱ type ۲ diabetic patients (۱۹ female, ۱۲ male) with mean age ۵۳.۰۳ ± ۸.۸۷ years were studied. Vitamin E supplementation for ۳ months had no positive effect on type ۲ diabetic patients. As FBS, TG and fasting insulin decreased but this decline was not significant. Also total Cholesterol, systolic and diastolic blood pressure changes were not remarkable. CONCLUSION: Results of this study showed that ۸۰۰ IU vitamin E administration for ۳ months could not improve blood glucose, lipids , HbA۱c, fasting insulin, systolic and diastolic BP in type ۲ diabetic patients.

Keywords:

Type ۲ diabetes , Vitamin E , Insulin , Glycated hemoglobin.