Oxidized LDL is Correlated with Urine Albumin in Type ۲ Diabetes Mellitus: A Case-Control Study

Objective: In patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. We designed a study for comparing the level of Ox-LDL in diabetic patients with Macro-albuminuria, Micro-albuminuria, versus Normo-albuminuric. Materials and Methods: One hundred and thirty five patients with type ۲ diabetes mellitus who had been referred to the Yazd Diabetes Clinic, from ۱۳۹۱ through ۱۳۹۲, were enrolled to our study. The ۲۴ hours urinary albumin excretion was measured and Macro-albuminuria defined as albumin excretion of greater than ۳۰۰mg per day and below ۳۰mg per day in normo-albuminuric group and between ۳۰-۳۰۰mg defined as Micro-albuminuria group. Plasma level of OX-LDL was measured. Results: The plasma OX-LDL level in patients with Macro-albuminuria was higher than those in Normo-albuminuric group, (۱۶.۱±۳.۶ U/ml versus ۸.۶±۱.۷ U/ml). There was a significant correlation between the OX-LDL and urine albumin in Macro-albuminuria and Micro-albuminuria groups. There was no significant correlation between the OX-LDL and HbA۱C level and diabetes duration. Conclusion: Significantly elevated plasma OX-LDL in patients with Macro-albuminuria suggests that OX-LDL may play an important role in the progression of diabetic nephropathy.

Keywords:

Diabetic mellitus , Oxidized LDL , Nephropathy.