Hypothyroidism and Celiac among Patients with Diabetes Mellitus Type I in Yazd, Iran a Descriptive Study

Objective: The autoimmune diseases tend to coexist with diabetes mellitus type I (T۱DM). The concomitance of these two types of diseases will lead to poor glycemic control beside their own complications. In this study the prevalence of thyroid disorder and celiac disease among T۱DM patients in Yazd, Iran was evaluated. Materials and Methods: all the patients diagnosed as T۱DM in Yazd younger than ۱۸ years old were investigated for the presence of thyroid disorders and celiac by measuring T۳, free T۴, TSH, Anti TPO and anti-tTG IgA. In positive celiac disease laboratory tes, intestinal biopsy was done to confirm the presence of this disease. Data gathered from all patients were analyzed using SPSS software version ۱۸th. Results: Eighty one patients consist of ۳۸ boys and ۴۳ girls involved in our study. Six patients (۷.۴%) consist of ۴ girls and ۲ boys presented hypothyroidism with positive Anti TPO. Two patients (۲.۴%) presented positive anti-tTG IgA that both were confirmed by intestinal biopsy. Conclusion: due to the considerable prevalence of thyroid disorders and celiac disease among T۱DM patients, serologically screening for autoimmune diseases and then annually for any new onset is suggested.

Keywords:

Diabetes mellitus type I , Celiac disease , Thyroid disorder , Auto immune disease