The Effect of Ziziphus Jujuba Fruit Extract in Diabetic and Non-Diabetic Rat
Publish place: Iranian Journal of Diabetes and Obesity، Vol: 6، Issue: 1
Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJDO-6-1_006
تاریخ نمایه سازی: 16 آبان 1402
Abstract:
Objective: Herbal medicine and medical plants such as Ziziphus Jujuba are widely used in the treatment of diseases such as diabetes mellitus. We investigated the effects of ethanol extracts of Ziziphus Jujuba fruit on serum glucose, triglycerides, LDL-cholesterol, HDL-cholesterol, cholesterol and activities of aminotransferase enzymes in streptozocin-induced diabetic adult male rats.
Materials and Methods: Adult Wistar rats were rendered hyperglycemic. Animals were divided into four equal groups (۷ per group). Animals in all groups were treated for ۱۴ days. Blood samples were collected from the heart of the animals.
Results: Continuous supplementation of ethanol extract in drinkable water of diabetic rats resulted to a significant decrease of fasting blood glucose, cholesterol and increase in high density lipoprotein levels after ۱۴ days (P۰.۰۵).
Conclusion: This paper discussed the antidiabetic effect of an alcoholic extract of Ziziphus Jujuba on streptozocin-induced diabetes in rats. Researchers showed that Streptozocin injection led to diabetes mellitus, which may be due to destruction of β cells of the islets of Langerhans.
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Authors
Hamid Reza Jamshidi
Department of Toxicology-Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd Iran.
Mohammad Hossein Mosaddegh
Department of Toxicology-Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd Iran.
Ali Reza Vahidi
Herbal Medicine Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mona Ghasemian
Student in Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Nahid Haj Mohammadi
Student in Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.