The Effect of Combined Exercise Course and Aloe-Vera Supplementation on Renal Function and Lipid Profile in Type ۲ Diabetes Mellitus Patients: A Randomized Clinical Trial

Objective: Renal failure is a complication of diabetes. It can be the risk factor of cardiovascular disease. This study aimed to evaluate the effect of exercise course and Aloe-Vera supplementation on renal function and lipid profile in type ۲ diabetes mellitus (T۲DM) patients. Materials and Methods: This is a clinical trial double blind with pre-test and post hoc test analyses with a control group. The studied population included a group of T۲DM diagnosed patients among whom ۲۴ men (۴۰-۶۰years) were selected voluntarily and purposefully and were classified into three groups by balanced block randomization method, exercise(E), exercise + supplement (E+S), and control (C), (n=۸/group). Combined exercise was planned in two ۱۲-minute repetitive sets with ۷۰% ۱RM. Then the participants ran for two ۱۰- minute sets with ۷۰-۷۵% maximum heart rate intensity on treadmill. E+S participants consumed ۵۰۰ mg/day Aloe Vera for ۶ weeks. Obtained data by SPSS-۱۹ software were analyzed using co-variance analysis method with Bonferroni post hoc test (P-value<۰/۰۵). Results: Results showed that E and E+S significantly improved GFR (P-value=۰.۰۱۱) and E with or without Aloe-Vera consumption decreased creatinine levels (P-value=۰.۰۴۲) and increased HDL levels (P-value˂۰.۰۰۱). The results demonstrated that LDL and TG levels showed no significant difference in reaction to the combined exercise and supplementation. Conclusion: Combined exercise along with Aloe-Vera supplementation has had significant effect on improving renal factors and lipid profile of T۲DM diagnosed patients

Keywords:

Combined exercise , Type ۲ diabetes , High density lipoprotein , Low density lipoprotein , Creatinine