HbA۱c in Polycystic Ovary Syndrome as the Cardiac Risk Assessment

Objective: Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with hyperandrogenism marked with hirsutism and ovarian dysfunction. These conditions may lead to the risk of insulin resistance (IR), type ۲ diabetes, obesity, and cardiovascular disease. These conditions are related to PCOS complications hence our aim was to study and investigate the relationship between high-sensitivity C - reactive protein (hs-CPR) level and glycosylated hemoglobin (HbA۱c) level in PCOS patients. Materials and Methods: Female patients visiting the obstetrics and gynecology outpatient department (OPD), aged between ۱۹ and ۴۵ years with a body mass index (BMI) of ۲۵ to ۲۹ kg/m۲. The individuals fulfilling the National Institute of Health (NIH) criteria for PCOS; including amenorrhea or oligomenorrhea and had been clinically diagnosed with hyperandrogenism were served as subjects. Results: Two hundred and ten individuals with HbA۱c of ۵.۴% have a higher risk of cardiovascular disorders. The study showed the association between increased cardiac risk as measured by hs-CRP and patients with normal HbA۱c values with a sensitivity of ۷۷.۲% and specificity of ۷۵.۹۹%. The HbA۱c cutoff value can be used in the PCOS patients to assess the cardiac risk due to association of HbA۱c cut off value with false positivity rate of ۱۵.۲۴%. Conclusion: In PCOS patients with chronic low-grade inflammation, IR, and the degree of inflammation associated with HbA۱c value was observed.

Keywords:

HbA۱c , Polycystic ovary syndrome , hs-CRP , Cardiovascular disorder