The Comparison of the Protective Effect of L-Carnitine, Chromium and Vitamin D with Metformin on Liver, Antioxidant Enzyme Activity, and Iron Metabolism in Diabetic Rats
Publish place: Iranian Journal of Diabetes and Obesity، Vol: 13، Issue: 2
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJDO-13-2_003
تاریخ نمایه سازی: 16 آبان 1402
Abstract:
Objective: Due to the lack of information about the positive or negative effects of L-carnitine, chromium, vitamin D, and the uptake of a safe dietary supplement to reduce the effects of diabetes, it seems essential to determine the effects of these drugs on diabetes.
Materials and Methods: Wistar rats were divided into ۱۲ groups, control, diabetic, and intact, each of which was treated with metformin, L-carnitine, vitamin D, and chromium or a combination of L-carnitine, vitamin D, and chromium. The serum levels of liver function parameters, iron, TIBC, Catalase and GPX activities were measured. Data were statistically analyzed by one-way ANOVA using SPSS ۱۸ software. Statistical significance among the groups was determined using LSD test, and P-value< ۰.۰۵ was considered significant in all cases.
Results: AST activity in diabetic groups and those receiving chromium and L-carnitine has significantly reduced (P-value= ۰.۰۰۹). A significant reduction in ALT and ALP activity in the diabetic groups receiving vitamin D and combined and non-diabetic groups receiving metformin were observed, in contrast to a significant increase in ALT activity in diabetic recipients of L-carnitine (P-value= ۰.۰۰۹).
Conclusion: L-carnitine, chromium, and vitamin D supplements have synergistic effects and a combination of them has the best protective effect on factors that have been studied.
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Authors
Parisa Sheikh Samani
Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Kahin Shahanipour
Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Ali Noori Diziche
Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Mohammad Adibnejad
Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
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