Effects of silver nanoparticles on Staphylococcus aureus contaminated open wounds healing in mice: An experimental study
Publish place: Veterinary Research Forum، Vol: 8، Issue: 1
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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JR_VRFAN-8-1_004
تاریخ نمایه سازی: 25 آبان 1402
Abstract:
The microorganisms have been noted as the main cause of delayed wound healing.The most common pathogen causing the wound infections is Staphylococcus aureus. Silver nanoparticles (AgNPs) show ample antibacterial activities. In the present study, the effect of AgNPs on mouse wounds inoculated with S. aureus was investigated. Sixty male mice (۲۰ to ۳۰ g) were anesthetized, full-thickness skin wounds were made on their back and then the bacterial suspension was added to each wound bed. Treatments were administered on wound bed topically including gentamicin (۸ mg kg-۱), AgNPs (۰.۰۸ mg kg-۱, ۰.۰۴ mg kg-۱ and ۰.۰۲ mg kg-۱) and normal saline in the control group. Wound healing was monitored macroscopically by taking digital photographs on days ۰, ۷, ۱۴ and ۲۱ of the experiment. Topical application of gentamicin and AgNPs (۰.۰۸ and ۰.۰۴ mg kg-۱) significantly increased the rate of wound healing more than treatment with AgNPs at a dose of ۰.۰۲ mg kg-۱and normal saline. The presence of silver nanoparticles in AgNPs groups (especially ۰.۰۸ mg kg-۱) improved wound appearance better than other groups without silver nanoparticles (gentamicin and control groups) and led to lesser wound scars. According to data analysis, healing rate of treated mice with gentamicin and AgNPs (۰.۰۸ mg kg-۱) was significantly (p < ۰.۰۰۱) faster than treated mice with other AgNPs doses and normal saline. The results of current study introduced an in vivo nanosilver accelerating effects on the treatment of on S. aureus infected skin wounds.
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Authors
Masood Adibhesami
PhD candidate, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Malahat Ahmadi
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Amir Abbas Farshid
Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Farshid Sarrafzadeh-Rezaei
Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Bahram Dalir-Naghadeh
Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
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