Metabolomic profiling of liver tissues after acute administration of vardenafil in rats
Publish place: Veterinary Research Forum، Vol: 11، Issue: 3
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
View: 63
This Paper With 5 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_VRFAN-11-3_003
تاریخ نمایه سازی: 25 آبان 1402
Abstract:
Erectile dysfunction (ED) diseases have almost affected ۱۰۰ million men all over the world. Orally administered phosphodiesterase ۵ (PDE ۵) inhibitors are the most used pharmaceutical formulations for the treatment of ED. In this study, it is aimed to investigate the metabolomics feature of orally administered vardenafil in rats. To carry out the experimental procedure eight male Wistar albino rats were used. Their livers were gently removed and metabolomics profiles of each sample were determined by UPLC Q-TOF MS. Identification of metabolites was achieved by the METLIN database. Cluster analysis was also performed via Principle Component Analysis. Several metabolites were identified and results were evaluated by XCMS software. UPLC Q-TOF MS could be successfully applied to profile biomarkers and help us understand the molecular mechanisms of vardenafil usage. It was concluded that the level of some metabolites, responsible for the collagen synthesis and Kreb’s cycle, has been statistically significant after the vardenafil administration.
Keywords:
Authors
Onur Şenol
Department of Analytical Chemistry, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey
Şaziye Sezin Palabiyik
Department of Toxicology, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey
Beyzagül Polat
Department of Pharmacology, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey
Yücel Kadioğlu
Department of Analytical Chemistry, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey
Mehmet Emrah Yaman
Department of Analytical Chemistry, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :