Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients
Publish place: Middle East Journal of Cancer، Vol: 1، Issue: 1
Publish Year: 1389
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_MISJ-1-1_005
تاریخ نمایه سازی: 25 آبان 1402
Abstract:
Introduction: Pancreatic cancer has not been well studied, especially in developing countries.Materials and Methods: We studied the variations in genetic mutations in pancreatic adenocarcinoma between Moroccan and Egyptian populations. The molecular pathology of ۳۰ tumors from a large hospital in Casablanca, Morocco were examined and compared with the findings of ۴۴ tumors from the Gharbiah Governate in Egypt. K-ras mutations in codons۱۲ and ۱۳ in addition to p۵۳ mutations in exons ۵-۸ were evaluated.Results: Overall, differences in the rates of K-ras mutations were not statistically significant (۴۸.۰۰ and ۳۴.۰۹%, respectively); however differences in rates of p۵۳ mutations were statistically significant with p۵۳ mutations more common in Moroccan tumors than in Egyptian tumors (۴۶.۶۷ and ۱۶.۲۸%, respectively). GTmutations of the K-ras gene were most commonly seen Egyptian tumors, whereas GAmutations were the most common type of mutations in Moroccan tumors. Logistic regression analysis showed that a p۵۳ mutation in any exon as well as a p۵۳ mutation in exon ۵ predicted the country of residence and those mutations occurred more frequently in Moroccan patients. Conclusion: Our study shows that differences exist within the Arab population in the molecular pathology of both the K-ras and p۵۳ genes. Further studies are necessary to clarify the differences in molecular pathways of pancreatic cancer in the Middle East and to investigate the role of environmental and/or genetic factors related to those pathways.
Authors
Sara Robinson
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Amr Soliman
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Mehdi Karkouri
Department of Pathology, Mohammed V University, Casablanca, Morocco
Hoda Omer
Department of Pathology, Tanta Cancer Center, Tanta, Egypt
Joel Greenson
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA