Prothrombin G۲۰۲۱۰A Mutation is not a Risk Factor for Pediatric Acute Lymphoblastic Leukemia in Western Iran

Background: We conducted the present study to investigate the frequency of prothrombin G۲۰۲۱۰A mutation among acute lymphoblastic leukemia patients and healthy individuals from Western Iran and to detect the possible association between this mutation and the risk of acute lymphoblastic leukemia in our population.Methods: The studied groups consisted of ۹۲ children with acute lymphoblastic leukemia and ۲۴۹ age- and sex-matched healthy children from Western Iran. The prothrombin G۲۰۲۱۰A mutation was identified by PCR-RFLP using the restriction enzyme of Hind III.Results: The prevalence of prothrombin ۲۰۲۱۰ GA genotype was ۶.۵% in patients and ۳.۲% in controls (P=۰.۱۷). The frequency of the A allele in patients was ۳.۳% and in controls it was۱.۶%.Conclusion: The present study indicates the absence of any significant differences in the frequency of the prothrombin G۲۰۲۱۰A mutation between acute lymphoblastic leukemia patients and healthy individuals. The results suggest that this mutation may not be a risk factor for acute lymphoblastic leukemia in our population.