Expressions of YAP-۱, ANXA۱۰, and UNC۵D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance

Background: There is an ongoing need for targeted therapy and systemic treatment protocols for papillary thyroid carcinoma (PTC) patients. Yes activated protein-۱ (YAP-۱) has been found to control many targets of Hippo pathway. Annexin family is a huge family playing many roles in cellular processes. Annexin A۱۰ (ANXA۱۰) is a member of annexin family. Uncoordinated-۵D (UNC۵D), a recently discovered Unc۵ family member which is found in normal tissues and downregulated in cancer cell lines and tissues. Aim of the study was to assess the expression of YAP-۱, ANXA۱۰, and UNC۵D in PTC and in non-neoplastic tissues of thyroid gland using immunohistochemistry to evaluate their clinical significance and prognostic values in PTC patients.Method: In the present prospective study, we took samples from ۶۰ patients with PTC and ۳۰ samples from non-neoplastic thyroid tissues for YAP-۱, ANXA۱۰, and UNC۵D immunohistochemistry. All the patients were followed up for assessment of the prognostic, clinical, and pathological of their expression.Results: Upregulation of YAP-۱ and ANXA۱۰ in addition to downregulation of UNC۵D was found in PTC tissues more than non-neoplastic thyroid tissues. In PTC tissues, there were positive associations between high YAP-۱ and ANXA۱۰ expression, low UNC۵D expression, tumor size (P = ۰.۰۲۲, ۰.۰۱۱, ۰.۰۱۴), presence of lymph node metastases (P = ۰.۰۰۵, < ۰.۰۰۱, ۰.۰۰۸), and inferior disease-free survival rate (P = ۰.۰۰۳, ۰.۰۱, ۰.۰۳).Conclusion: Upregulation of YAP-۱ and ANXA۱۰ expression and downregulation of UNC۵D was associated with bad clincopathological criteria, disease progression, high incidence of disease recurrence, and poor survival.

Keywords:

YAP-۱ protein , ANXA۱۰ , UNC۵D , PTC , Immunohistochemistry , Prognosis