Prognostic and Clinicopathological Implications of NUSAP۱, MELK and L۱CAM Immunohistochemical Expression in Cervical Cancer

Background: Evaluation of cancer cervix prognosis is highly needed for novel targeted therapy and improved outcomes. Nucleolar and spindle associated protein ۱ (NUSAP۱) is a novel biomarker that has roles in spindle formation and mitotic progression. Maternal embryonic leucine zipper kinase (MELK) is involved in cell cycle control and carcinogenesis. The L۱ cell adhesion molecule (L۱-CAM) plays an essential role in cell migration. This study aimed to investigate NUSAP۱, MELK, and L۱CAM immunohistochemical expression in cancer cervix tissues and detect their prognostic roles. Method: In this prospective cohort study, we evaluated NUSAP۱, MELK, and L۱CAM expressions of sections from ۶۲ cervical carcinoma cases using immunohistochemistry. Results: NUSAP۱, MELK, and L۱CAM expression correlated with tumor high grade, advanced FIGO stage, poor survival rates, and higher recurrence rate after successful therapy (p <۰.۰۰۱). Conclusion: Expression of NUSAP۱, MELK, and L۱CAM in cancer cervix was associated with poor prognosis.

Keywords:

Cancer cervix , Immunohistochemistry , Prognosis , NUSAP۱ , MELK , L۱CAM