Intravenous Immunoglobulin Resistant Kawasaki Disease
Publish place: Journal of Pediatrics Review، Vol: 1، Issue: 1
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JPRE-1-1_006
تاریخ نمایه سازی: 8 آذر 1402
Abstract:
ABSTRACT
Kawasaki disease is a systemic vasculitis that mainly affects younger children. Although the definite cause still remains unknown but the clinical and epidemiologic findings discuss an infectious cause. The prevalence of incomplete Kawasaki disease reported ۱۵ to ۳۶.۲%, and it is more frequent in the extremes of the age spectrum. Non delayed treatment of disease should be initiated because of critical cardiac vascular complications. Up to ۱۵% - ۲۵% of patients with Kawasaki disease who remain febrile after administration of first dose of intravenous immunoglobin plus aspirin are classified as refractory disease. These intravenous immunoglobin resistant cases are at increasing risk for coronary artery complications. The strategy on prediction of potentially non responder and treatment of intravenous immunoglobin resistant patients is now controversial but some useful points were recommended.
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Authors
Mohammad Reza Navaeifar
Nosocomial Infection Research Center
Mohammad Sadegh Rezai
Department of Pediatric Infectious Disease