A Meta-Analysis of Prenatal and Maternal Risk Factors for Childhood Leukemia in Iran, Case-Control Studies Approach
Publish place: Journal of Pediatrics Review، Vol: 6، Issue: 1
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JPRE-6-1_001
تاریخ نمایه سازی: 9 آذر 1402
Abstract:
Context: Few possible risk factors for childhood leukemia including environmental, genetic, and infectious causes can be explained by epidemiologic studies but the etiology of most childhood leukemia is unknown.
Objectives: In this systematic review and meta-analysis, we aimed to find the relationship between prenatal and maternal risk factors with leukemia children in Iran.
Data Sources: Relevant studies published in English databases (PubMed, Scopus, and ISI) and Persian databases (Magiran, Medlib, SID, and Iran Medex)) were systematically searched.
Study Selection: The study included all case-control studies that estimated the effects of prenatal and maternal risk factors on leukemia children in Iran during years ۲۰۰۴ to ۲۰۱۶, and a standardized manner was used for the extraction of information.
Data Extraction: After reviewing all searched articles (title, abstract, and entire text), irrelevant studies were excluded and related ones were selected.
Results: We identified ۱۰ case-control studies. The first relative history of leukemia was associated with four times raises of leukemia in children aged ۱۵ > years (OR = ۴.۵۸, ۹۵% CI = ۱.۱۶ - ۷.۹۹). Other significant risk factors were mothers with birth order ۳ ≤ and maternal age > ۳۵, ORs for these factors were respectively (OR = ۲.۳۹, ۹۵% CI = ۰.۷۹ - ۳.۹۹) and OR = ۲.۲۵, ۹۵% CI = ۱.۰۹ - ۳.۴۱).
Conclusions: Our results indicate that among maternal and prenatal risk factors, birth order ≥ ۳, birth weight < ۲,۵۰۰ g, and first relative history of leukemia increased the risk of childhood leukemia; in contrast, breastfeeding was a protective factor.
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Authors
Yousef Veisani
Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, IR Iran
Ali Delpisheh
Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, IR Iran