Background: Breast cancer is the most common cancer in women. Breast-conserving surgery (BCS) has been increasingly applied to eligible patients. One of the most important points in BCS is to provide clean surgical margins. This study aimed to share the re-excision results of those having positive surgical margins in intra-operative evaluation among BCS patients, and to discuss the intra-operative evaluation in the light of the literature. Materials and Methods: The data (patient files, surgery notes and pathology reports) of ۲۰۳ patients who had undergone BCS for breast cancer between January

Background: Several studies have reported the role of platelet activation, platelet volume (MPV) and other indices in breast cancer but the data is inconsistent and diverse. The aim of this study was to systematically evaluate the role of platelet activation and platelet volume indices in women with BC as predictors of cancer progression and poor prognosis. Methods: The patients were recruited from our local oncology center from ۲۰۱۹ to ۲۰۲۰ following ethics approval. In total, ۸۰ patients with locally invasive BC, ۲۰ metastatic, and ۱۰۰ controls were recruited. ADP-induced platelet activation was assessed by light-transmission aggregometry. Platelet P-selectin (CD۶۲P) expression with and without ADP stimulation was assessed by flowcytometry. The comprehensive analysis of platelet count and platelet volume indices (PVIs) (MPV, PDW, MPV/P and PDW/P) was conducted. Data was analyzed in relation to tumor pathology, hormone receptors (ER, PR, HER-۲) and proliferation index Ki-۶۷. Regression analyses were conducted to predict poor prognosis, tumor aggression and metastatic potential. Results: We found a significant increase in platelet aggregation (MA), CD۶۲P expression, CD۶۲P+ADP, MPV, PDW, MPV/P and PDW/P in the metastatic group compared to the locally invasive group. Univariate regression analysis showed significance for ADP MA, CD۶۲P+ADP, MPV and PDW/P. Conclusion: MPV/P and PDW/P can be used as simple low-cost predictors of cancer progression and poor prognosis. We conclude platelet activation and specific platelet indices can help predict prognosis in females with BC.

Keywords:

Breast cancer , Platelet activation , Platelet indices , Metastasis , Cancer , Prognosis