Spatial memory-enhancing effects and antioxidant activities of leaf and stem bark methanol extracts of Prunus africana in scopolamine-treated mice
Publish place: Journal of Herbmed Pharmacology، Vol: 12، Issue: 2
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_HERM-12-2_016
تاریخ نمایه سازی: 14 آذر 1402
Abstract:
Introduction: Conventional medicines for Alzheimer’s disease (AD) have little efficacy and are linked to several severe effects, necessitating alternative therapy. The current study investigated the memory-enhancing effects and antioxidant activities of stem bark and leaf MeOH extracts of Prunus africana in scopolamine-induced amnesic mice. Several inclusions build up in brain tissue during AD progression and the brain clears them oxidatively. This makes the antioxidant activity a vital requirement for plant extracts that are used with great success to manage AD.
Methods: In this study, for each plant extract, thirty Swiss albino mice were randomly assigned to six groups; extract-treated, reference drug control, normal control, and negative control groups. The mice were then subjected to the Morris water maze task for four consecutive days, euthanized and their whole brains were assessed for antioxidant activities.
Results: The studied extracts significantly (P < ۰.۰۱) reduced escape latencies of experimental mice in a dose-related manner, depicting their considerable memory-enhancing effects. The extracts also displayed significant (P < ۰.۰۱) enzymatic and non-enzymatic antioxidant activities.
Conclusion: The leaf and stem bark MeOH extracts of P. africana possess phytocompounds with spatial memory-enhancing effects and antioxidant activities.
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Authors
David Nyaga Ngai
Department of Biochemistry, Microbiology and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, P.O. Box ۴۳۸۴۴-۰۰۱۰۰, Nairobi, Kenya
Cromwell Mwiti Kibiti
Department of Pure and Applied Sciences, Technical University of Mombasa, P.O. Box ۹۰۴۲۰-۸۰۱۰۰, Mombasa, Kenya
Mathew Piero Ngugi
Department of Biochemistry, Microbiology and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, P.O. Box ۴۳۸۴۴-۰۰۱۰۰, Nairobi, Kenya