Assessment of Hydroxyproline Content in Rabbit Achilles Tendon Treated with Platelet Rich Fibrin (PRF)
Publish place: Archives of Razi Institute journal، Vol: 78، Issue: 3
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_ARCHRAZI-78-3_018
تاریخ نمایه سازی: 6 دی 1402
Abstract:
Tendon is similar to rope and consists of strong, flexible, dense connective tissue. Tendon disorder healing is challenging as it is an avascular tissue. The repaired tissue appears scar-like, and its biomechanical properties never ultimately return to their pre-injury state. This study aimed to evaluate the effects of platelet-rich fibrin (PRF) on the hydroxyproline content of the Achilles tendon after injury. For this purpose, ۲۴ adult rabbits weighing ۱.۵-۲ kg were used in this study. The animals were divided into three groups of eight, including the advanced-PRF (A-PRF) group in which the tendon defect was treated with xenogeneic A-PRF, the leukocyte-PRF (L-PRF) group in which xenogeneic L-PRF was used for tendon defect treatment, and a control group which was treated with normal saline. Hydroxyproline concentration was measured ۱ and ۲ months after the operation. Clinically, lameness was improved in the A-PRF group, compared to the L-PRF and control groups at the end of the third week after the surgery. Hydroxyproline level was significantly increased in the A-PRF group (۵۰.۳۳±۱.۴۴), compared to the L-PRF (۴۴.۷۰±۱.۱۲) and control (۳۵.۹۷±۱.۰۵) groups ۲ months after the surgery (P<۰.۰۵). Moreover, the L-PRF group showed an increase in hydroxyproline content, compared to the control at the same period. The results of the current study demonstrated that A-PRF could enhance the hydroxyproline content of rabbit Achilles tendon after injury. Xenogenic PRF can be used as an alternative biomaterial to accelerate and regenerate tendon tissue.
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Authors
S Salim Abd Al-Hussein
Department of Veterinary Surgery and Obstetric, University of Basra, Basra, Iraq
A. A Ibrahim Al Dirawi
Department of Veterinary Surgery and Obstetric, University of Basra, Basra, Iraq
R Majeed Naeem Al-Khalifah
Department of Veterinary Surgery and Obstetric, University of Basra, Basra, Iraq
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