Serological Detection for Toxoplasmosis among Patients with Covid-۱۹ in Thi-Qar Province

Covid-۱۹ is a viral disease that affects humans caused by a type of virus belonging to the family Coronaviridae called the SARS-CoV-۲ virus. The parasitic infection associated with this disease affects the host's immune response regulation. The levels of IgG and IgM of Toxoplasma gondii in the serum of patients with COVID-۱۹ were measured by immunoassay of the patient’s sera by ELISA. Also, the level of interferon-gamma (IFN-γ) in a covid-۱۹ patient with or without Toxoplasmosis was evaluated. ۱۲۰ samples were collected, ۶۰ were positive for COVID-۱۹, confirmed by clinically and radiographic examination, and ۳۰ were in the control group. The results showed a significant difference between the infection with Covid-۱۹ and T. gondii during the chronic phase of Toxoplasmosis compared to the negative relationship in the acute phase. The results of INF-γ levels among Covid-۱۹ patients were positive for all samples included in the test (۳۰ Covid-۱۹ patients and ۳۰ patients COVID-۱۹(+)/T. gondii IgG) compared to the control group. The chronic form of Toxoplasma disease, due to change in the production of this interferon, the COVID-۱۹ infection has changed.

Keywords:

Toxoplasma gondii , Interferon Gamma , Immune response , covid-۱۹