Protective Effects of N-Acetylcysteine on Dipentyl Phthalate Induced Cognitive Dysfunction and Brain Oxidative Stress in Mice
Publish place: Pharmaceutical and Biomedical Research، Vol: 8، Issue: 3
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_PBRE-8-3_003
تاریخ نمایه سازی: 10 دی 1402
Abstract:
Background: Dipentyl phthalate (DPeP) is a plasticizer compound commonly used in polyvinylchloride plastic to enhance softness and flexibility. They are not bound covalently to plastic polymers; therefore, they can dissolve into the environment and adversely affect the health of humans and animals.
Objectives: The aim of this study was to investigate the effect of DPeP on cognition and protective effects of N-acetylcysteine (NAC) on DPeP induced alteration in cognitive behaviour and oxidative stress markers in mice.
Methods: Mice were orally treated with ۲ doses (۳۳ mg/kg and ۱۰۰ mg/kg) of DPeP for ۲۸ days. Cognitive functions were assessed using spatial navigation tasks on the Morris water maze and the step-down latency in the passive avoidance apparatus. Oxidative stress was assessed by examining the levels of malondialdehyde, glutathione, ferric reducing antioxidant power, and ۸-hydroxy-deoxyguanosine levels in the whole brain of mice.
Results: There was a significant increase in latency in spatial navigation tasks and a significant decline in the step-down latency in passive avoidance apparatus in the DPeP-treated group compared to the control groups. There was also a significant increase in the levels of oxidative stress following DPeP administration as seen with the rise in the levels of malondialdehyde, ۸-hydroxy-deoxyguanosine, and a fall in glutathione and ferric reducing antioxidant power levels.
Conclusion: The present study demonstrated that DPeP adversely affects learning and memory functions in mice by oxidative stress-mediated neuronal damage. These effects were attenuated by pretreatment with N-acetylcysteine.
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Authors
Sandhya Rani Gautam
Department of Pharmacology, University College of Medical Sciences & GTB Hospital, Delhi.
Seema Jain
Department of Pharmacology, University College of Medical Sciences & GTB Hospital, Delhi.
Proteesh Rana
Department of Pharmacology, University College of Medical Sciences & GTB Hospital, Delhi.
Basudev Banerjee
Department of Biochemistry, University College of Medical Sciences & GTB Hospital, Delhi.
Pramod Kumari
Department of Pharmacology, University College of Medical Sciences & GTB Hospital, Delhi.
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