Antibacterial and Wound Healing Activities of Topical Gel of Jatropha variegata Vahl Extract in Rats
Publish place: Pharmaceutical and Biomedical Research، Vol: 6، Issue: 4
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_PBRE-6-4_006
تاریخ نمایه سازی: 10 دی 1402
Abstract:
Background: Jatropha variegata Vahl is a well-known Yemeni medicinal shrub, used traditionally to treat wounds.
Objectives: To investigate the wound-healing and antibacterial properties of the J. variegata extract as a new gel formula.
Methods: The leaves and stems of J.variegata were collected from Ibb Province, Yemen, and extracted by maceration in methanol. To ensure the quality and effectivity of the extract, physicochemical and biological investigations were conducted. Finally, the extract was prepared as a gel dosage form for bacterial and experimental animal studies. Twelve female Albino rats were divided into three groups: each rat was inflicted by three wounds. The first wound was treated thrice a day using the gel containing the J. variegata extract, the second was treated by a gel without the extract, and the third was control. The first, second, and third groups were treated for ۵, ۱۰, and ۱۵ days, respectively, with follow-up of the wounds’ diameters. After treatment, the rats were anesthetized before analyzing the anatomy of the rats and the histological examination.
Results: The antibacterial activity of the extract was competent to the positive control against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli with a Minimum Inhibitory Concentration (MIC) of ۰.۰۵%. Similarly, ۱۰۰% of the wounds healed within ۱۵ days when treated using the gel containing the J. variegata extract. While just ۳۳% of the control group healed.
Conclusion: J. variegata exhibited high antibacterial activity against the targeted strains and remarkable wound healing activity when applied topically on the skin of rats in a gel dosage form. This finding proves an opening for further pharmacological, toxicological, and clinical studies.
Keywords:
Authors
Abdulkarim Kassem Alzomor
Department of Pharmacy, Faculty of Medicine and Health Sciences, Thamar University, Dhamar, Republic of Yemen.
Nahlah Mansour Sallam
Department of Pharmacy, Faculty of Medicine and Health Sciences, Thamar University, Dhamar, Republic of Yemen.
Shehab Aldeen Al-Fotaihy
Department of Pharmacy, Faculty of Medical Sciences, Al-Nasser University, Sana’a, Republic of Yemen.
Bassam Al-Moliki
Department of Pharmacy, Faculty of Medical Sciences, Al-Nasser University, Sana’a, Republic of Yemen.
Badr Aldeen Al-Zohairy
Department of Pharmacy, Faculty of Medical Sciences, Al-Nasser University, Sana’a, Republic of Yemen.
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