A Review of Immune Landscape of Clonal Hematopoiesis: Progression and Prospects for the Future

Context: Clonal hematopoiesis (CH), characterized by the clonal proliferation of mutant hematopoietic cells, is frequently observed in older individuals. It is widely recognized that ageing leads to somatic mutations in hematopoietic stem cells, increasing the risk of developing various diseases later in life. However, the impact of these clonal hematopoiesis-related mutations on the activation and regulation of the immune response remains uncertain. Evidence acquisition: To address this knowledge gap, a thorough review of the existing literature on clonal hematopoiesis and immune dysregulation was conducted. Relevant studies were systematically searched and their key findings were carefully analyzed to provide a comprehensive overview. Results: The review shows that mutations associated with clonal hematopoiesis have a significant impact on the modulation of immune responses in the body. These mutations are found to contribute to immune dysregulation, which has important implications for disease progression in the elderly.  Conclusion: This review highlights the importance of studying immune dysregulation in the context of clonal hematopoiesis. By unravelling the relationship between CH-related mutations and immune responses, we can improve our understanding of disease progression in the elderly and identify promising therapeutic targets. This knowledge can inform the development of innovative interventions for improved disease management.

Keywords:

Clonal hematopoiesis , Immune dysregulation , T lymphocytes , B lymphocytes