Adamantiades-Behcet's disease: demographic and clinical comparison between the Iranian and the multinational german population
Publish place: Rheumatology Research، Vol: 9، Issue: 1
Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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JR_RHRE-9-1_006
تاریخ نمایه سازی: 14 بهمن 1402
Abstract:
Adamantiades-Behçet’s disease (ABD) is a chronic, recurrent inflammatory disease with an unclear aetiology. Major and minor clinical signs characterize ABD. Major signs generally comprise oral and genital aphthae and skin and eye manifestations. Minor signs include joint, neurological, and gastrointestinal symptoms and vascular involvement. This work aims to compare the prevalence and clinical manifestations of ABD using available study results from Iran and Germany.This report is based on statistical data from Iran and Germany. A long-term study over ۳۵ years from the Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, and a large German epidemiological study dealing with data from the German Registry for ABD and data on the disease in Europe are the information sources. Additionally, data from recent ABD studies listed in PubMed are used.Although the prevalence of ABD in Iran, with ۸۰ patients per ۱۰۰,۰۰۰ inhabitants, is markedly higher than in Germany, with ۴.۲ patients per ۱۰۰,۰۰۰ inhabitants, the male-to-female ratio and age of onset are similar in the two populations. In Iran, the male-to-female ratio is ۱.۳:۱, and the average onset age is ۲۶ ± ۱۱.۳ years. In Germany, the male-to-female ratio is ۱.۴:۱, and the average onset age is ۲۷.۷ ± ۱۱.۶ years. The incidence of the disease is decreasing, both in Iran and other parts of the world.Recurrent oral aphthae were the most common onset manifestation in patients of both Iran (۸۲.۷%) and Germany (۸۴.۵%), with ocular manifestations more common onset signs in Iran (۸.۷%) than in Germany (۵.۱%). Except for recurrent genital ulcers, which were more common in women in both countries, all other clinical signs – except oral aphthae – were more common in male patients in both countries. Minor clinical signs differed.A markedly different prevalence was observed in the study populations of Iran and Germany, with the disease being more common in Iran. However, despite the different origins, demographics and major clinical signs of ABD were similar in both countries. ABD is most frequently detected in young patients.
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Authors
Fatemeh Afagh Abedi Mamaghani
DGP- Deutsche Gesellschaft fuer Pneumologie Aerztekammer Nordrhein
Farhad Shahram
Professor of Rheumatology, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Fereydoun Davatchi
Rheumatology Research Ctr Shariati Hospital-Tehran Univ Jalal AI-Ahmad Avenue Tehran ۱۴۱۱۷ IRAN
Christos C Zouboulis
German Registry of Adamantiades-Behçet's Disease, Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
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