Catalyzing Kaempferol from Broccoli Fruit (Brassica oleracea var. italica) on Tyrosinase Protein for Regulation of Melanin Synthesis in-Slico

This study investigates the effectiveness of Kaempferol, a compound extracted from broccoli (Brassica oleracea var. italica), as a catalyst in controlling melanin production through its interaction with the tyrosinase protein. Utilizing a variety of computational tools, including Pymol, Pyrex, Protein Plus, and Lepinski Rule software, the study explores Kaempferol's binding affinity with tyrosinase and its molecular properties. The findings reveal Kaempferol's notable binding scores with tyrosinase and its structural stability as indicated by RMSD analysis. Furthermore, Protein Plus software confirms the interaction between Kaempferol and tyrosinase protein. Lipinski's analysis of Kaempferol shows it meets key pharmacokinetic properties like molecular weight, hydrogen bond formation potential, and reactivity. These insights establish a preliminary understanding of Kaempferol's role as a catalyst in melanin synthesis regulation, suggesting its potential application in treating skin pigment disorders.

Keywords:

kaempferol , Broccoli fruit (Brassica oleracea var. italica) , Protein tyrosinase , Melanin synthesis , In silico interaction