Antibacterial activity and ciprofloxacin-potentiation property of Berberis vulgaris asperma stem extracts on pathogenic bacteria
Publish place: Journal of Herbmed Pharmacology، Vol: 5، Issue: 3
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_HERM-5-3_006
تاریخ نمایه سازی: 26 بهمن 1402
Abstract:
Introduction: This study was planned to search the antibacterial activities of the ethanol and Chloroform extracts of Berberis vulgaris asperma stem and their synergistic effects with ciprofloxacin against some gram-negative pathogenic bacteria.Methods: Broth micro-dilution method was used for determination of minimum inhibitory concentrations (MICs) of the extracts alone or in association with ciprofloxacin and Phenylalanine-Arginine β-Naphtylamide (PAβN) as a positive control and efflux pumps inhibitor (EPI).Results: MIC determination indicated that the extracts from Berberis vulgaris asperma stem were able to inhibit the growth of all the studied bacteria within a concentration range of ۳۹۰۰ to ۳۷۵۰۰ μg/mL. Synergistic effects were noted between the extracts from Berberis vulgaris asperma stem extracts and ciprofloxacin on all tested bacteria except Acinetobacter bummani.Conclusion: Berberis vulgaris asperma stem extracts act as an antibacterial agent and potentiate ciprofloxacin effects on examined pathogenic bacteria.