Hepatoprotective and Hypolipidemic Effects of Carthamus tinctorius oil in Alloxan-induced Type ۱ Diabetic Rats

Introduction: Hepatoprotective and hypolipidemic effects of Carthamus tinctorius Linn.(Safflower) seed oil was investigated in diabetic rats. Methods: Diabetes was induced by administration of ۱۲۰ mg/kg alloxan monohydrate. The seed oil of safflower at dose of ۲۰۰ mg/kg was administered as single dose per day to diabetic rats for a period of ۲۸ days. The effect of oil on blood glucose level was measured in the diabetic rats. Serum lipid profile [total cholesterol (TC), triglycerides (TGs), low density (LDL) and high density lipoprotein (HDL) and enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were also determined. Results: Levels of blood glucose, TC, TGs, LDL, ALT, AST and ALP decreased and HDL increased in alloxan induced diabetic rats after treatment with ۲۰۰ mg/kg safflower seed oil for ۲۸ days. Conclusion: The present study demonstrates that seed oil of safflower seems to be useful for the prevention of diabetes complications.