Effect of nanocurcumin on fertility in murine model of polycystic ovary syndrome
Publish place: Veterinary Research Forum، Vol: 15، Issue: 2
Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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JR_VRFAN-15-2_008
تاریخ نمایه سازی: 27 بهمن 1402
Abstract:
The precise pathophysiology of polycystic ovary syndrome (PCOS) is not well-founded. In an attempt to fill this gap, the current study was executed to probe the effect of nanocurcumin (NCC) on ovarian tissue, in vitro fertilization (IVF) and pre-implantation embryo development in a mouse model of PCOS. Fifty adult female mice were randomly categorized into five equal groups including non-treated control and PCOS (receiving ۰.۲۰ mg estradiol valerate (EV) intra-peritoneally once a day for ۲۱ days) as well as NCC۱۲.۵۰ + PCOS, NCC۲۵ + PCOS and NCC۵۰ + PCOS (receiving respectively ۱۲.۵۰, ۲۵.۰۰ and ۵۰.۰۰ mg kg-۱ NCC daily along with EV injection through oral gavages for ۲۱ days) groups. Subsequently, ovarian histo-architecture and total anti-oxidant capacity, and malonaldehyde and catalase levels as well as in vitro fertilizing potential, early embryonic development and serum testosterone concentration were analyzed. Results showed that NCC in a dose-dependent manner improved ovarian cyto-architectural organization and oxidant/anti-oxidant balance along with IVF rate and pre-implantation embryo development in PCOS mice. These findings revealed that NCC at the doses of ۲۵.۰۰ and ۵۰.۰۰ mg kg-۱ could alleviate PCOS-linked reproductive disruptions in female mice.
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Authors
Zahra Aaly-Gharibeh
DVM Graduate, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran
Mohammadreza Hosseinchi
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran
Ali Shalizar-Jalali
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
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