Comparison the Effect of Ciprofloxacin Versus Amoxicillin and Metronidazole as an Adjunctive Therapy to Full Mouth Scaling and Root Planing of Chronic Periodontitis

Background: So many people worldwide have chronic periodontitis. Chemotherapeutic agents can reduce host responses to bacterial pathogens and as a result reduce bone loss. Objectives: The aim of this study was to compare the effect of antibiotics such as amoxicillin and metronidazole (AMX+MTZ) with ciprofloxacin (CPF) as an adjunct to scaling and root planing (SRP) in pocket depth (PD) and clinical attachment loss (CAL) in patients with moderate to severe chronic periodontitis. Methods: In this randomized double-blinded placebo-controlled clinical trials, ۴۵ patients with chronic moderate to severe periodontitis were randomly divided into ۳ groups: the control group which received SRP plus placebo, the test ۱ group which received SRP plus AMX+MTZ, and the test ۲ group which received SRP plus CPF. PD and CAL were measured in each group at ۳ time points (baseline, ۱ month and ۳ months after SRP). Statistical analysis was done using a paired t test and ANOVA. Results: Mean PD and CAL in the test groups were compared to the control group and no significant changes were found (P<۰.۰۵). Most changes in PD and CAL were seen at one month after intervention. Better outcomes were seen in the test groups (test ۲ better than test ۱). Conclusions: AMX+MTZ or CPF as an adjunct to SRP had better outcomes but did not have any significant impact on reducing PD and CAL over one ۱ and ۳ months after treatment in patients with chronic periodontitis.