The efficacy of ۱۰۰ and ۳۰۰ mg gabapentin in the post operative pain in carpal tunnel syndrome surgery

Introduction: Pharmacological interventions, such as gabapentin, have been utilized to alleviate the symptoms of CTS, but the optimal dosage remains uncertain. This article aims to review and compare the efficacy of two different doses of gabapentin, ۱۰۰ mg and ۳۰۰ mg, in the treatment of carpal tunnel syndrome. The findings of this review may provide valuable insights for clinicians in selecting the appropriate dosage of gabapentin, balancing the need for pain relief with the potential for adverse effects.Methodology: Following surgery, patients were administered their assigned study medication (۱۰۰ mg gabapentin, ۳۰۰ mg gabapentin, or placebo) orally, ۱ hour before the procedure. The study medication was prepared by a pharmacist who was not involved in data collection or analysis. Both the patients and the investigators assessing the outcomes were blinded to the treatment assignment.Results: Post hoc analyses using Tukey's test were conducted to assess specific between-group differences in pain scores. At ۱ hour postoperative, there was no significant difference in pain scores between the three groups (p>۰.۰۵). However, starting from ۲ hours postoperative and continuing at all subsequent time points, both the ۱۰۰ mg and ۳۰۰ mg gabapentin groups demonstrated significantly lower pain scores compared to the placebo group (p<۰.۰۰۱).Conclusion: The results of this study demonstrate that both ۱۰۰ mg and ۳۰۰ mg doses of gabapentin are effective in reducing postoperative pain following CTS surgery. The ۳۰۰ mg dose exhibited superior analgesic efficacy compared to the ۱۰۰ mg dose, as evidenced by significantly lower pain scores and reduced rescue analgesia consumption.

Keywords:

gabapentin , treatment , carpal tunnel syndrome , Pain