Determination and Comparison of the Effect of Ibuprofen and Acetaminophen on Postpartum Hypertension in Pregnant Women with a History of Preeclampsia

Epigenetic silencing of MLH۱ in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity, and reduced recurrence-free survival Background: The aim of this study was to determine which of the two drugs of ibuprofen, as a common non-steroidal anti-inflammatory drugs NSAID, and acetaminophen would have the least effect on postpartum hypertension in patients with preeclampsia.Methods: Clinicodemographic data including age, gestational age at delivery, body mass index, parity, and route of delivery, were collected through interviews with patients and reviewing patient records. In this double-blind clinical trial, among ۸۴ patients included in the study, ۴۲ patients were randomly assigned into the acetaminophen (۶۵۰ mg every ۶ to ۲۴ hours) and ۴۲ patients into the ibuprofen (۶۰۰ mg every ۶ to ۲۴ hours) group. Results: The two groups were not significantly different in terms of mean age (p = ۰.۳۲۲), body mass index (p = ۰.۹۵۰), route of delivery (p = ۰.۶۵۷), parity (p = ۰.۸۱۸), and mean systolic (p = ۰.۵۳۰) and diastolic blood pressure (p = ۰.۶۹۱). Following the intervention, the duration of blood pressure control (p = ۰.۱۸۲), mean systolic blood pressure (p = ۰.۳۷۱), and mean diastolic blood pressure (p = ۰.۱۳) were not significantly different in the acetaminophen and ibuprofen groups. There was no significant difference between the two groups in terms of the number of patients and the dosage of opioids used.Conclusion: The results revealed that in patients with preeclampsia, acetaminophen and ibuprofen to control postpartum pain have a similar impact on blood pressure.

Keywords:

Ibuprofen , Acetaminophen , hypertension , Pregnant women , Preeclampsia