The Role of Vitamin D Binding Protein and Vitamin D Level in Mortality of Sepsis Patients

Background: Vitamin D plays crucial roles in immune cell function, including macrophage activation, immune response modulation, and antimicrobial peptide production. Low vitamin D levels can result in reduced immune response, heightened inflammation, and impaired organ function, thereby exacerbating sepsis severity and impacting patient prognosis. This study investigates the influence of vitamin D binding protein expression and vitamin D levels on the mortality of septic patients. Methods: This analytical observational study employs a case-control approach and involves patients at the Critical Care Unit of Dr. M. Djamil General Hospital in Padang, Indonesia. The study comprises ۴۰ patients in the case group and ۴۰ patients in the control group. Vitamin D and vitamin D binding protein levels are assessed using the enzyme-linked immunosorbent assay method. Results: Vitamin D and vitamin D binding protein levels were observed to be lower in the case group compared to the control group. In the case group, the majority of patients had vitamin D binding protein levels below ۲۰۰ µg/mL. A significant association was found between vitamin D levels and mortality in sepsis patients (P< ۰.۰۵). Patients with vitamin D levels below ۲۰ µg/mL faced a ۲.۵۴ times higher risk of mortality than those with levels exceeding ۲۰ µg/mL. Conclusions: Diminished levels of vitamin D binding protein and vitamin D contribute to an increased risk of mortality in septic patients.

Keywords:

Antiinflammation , Mortality , Sepsis , Vitamin D Binding Protein , Vitamin D level.