The Effect of Terazocin and Prednislone in the Expulsion Therapy for Symptomatic Distal Urethral Stones

Background & Aims: [alpha]۱-Adrenergic blockers have recently been shown to increase the rate of spontaneous passage of distal urethral stones. In this study the clinical role of Terazocin and Prednisolone in expulsion therapy of symptomatic distal urethral stones was assessed. Methods: The total number of ۱۰۶ patients between ۲۰-۶۸ years old (Mean ۳۹.۰۵ years) who had lower ureteral stones with size of ۵-۱۰mm were selected in this prospective study. The patients were randomly divided into ۲ equal groups; treatment group received Terazocin (۵mg daily) plus Prednisolone (۵mg daily), and control group received only analgesics. Hydration was recommended simultaneously. The treatment duration considered for ۱۰ days to prevent the side effects resulting from prolonged corticosteroid therapy. Results: Two groups had no significant difference based on age, sex and stone location. In treatment group mean stone diameter was ۷.۴۵±۱.۷۰۵mm and in control group it was ۶.۷±۱.۷۵mm. The rate of expulsion for the treatment and control groups were ۶۲.۳% and ۳۷.۷% respectively that showes a significant difference between two groups (P<۰.۰۰۱). In the treatment group the number of pain episodes and analgesic (Morphin) intake was found to be lower compared to the control group. Conclusion: Simultaneous administration of terazosin ([alpha] ۱-Adrenergic blocker) and Prednisolone (corticosteroid) can increase the frequency of spontaneous passage of distal urethral stones.

Keywords:

Terazosine , Prednisolone , Urinary tract stones