Comparison of Serum CA-۱۲۵ Level in Ruptured and Unruptured Tubal Pregnancies in Yazd/Iran during ۲۰۰۱-۲۰۰۶

Background & Aims: This study aimed to determine if serial measurement of serum CA-۱۲۵ level could be used as a useful test in the differential diagnosis of intact and ruptured tubal pregnancies. Methods: In a single-blind prospective controlled clinical study, ۵۹ women with tubal pregnancy of ۶– ۱۲ weeks (۲۶ women with ruptured tubal pregnancy, ۳۳ women with intact tubal pregnancy and ۵۹women with normal intrauterine pregnancy of the same gestational age as control group) were studied prospectively. Serum CA-۱۲۵ levels were measured in all women and compared among three groups. Results: Demographic features (age, gestational age, parity and educational level) were not significantly different in three groups. CA-۱۲۵ level in ruptured tubal pregnancy group was significantly higher than that in control group (P = ۰.۰۴). Both these two groups had higher levels of CA-۱۲۵ comparing to the intact tubal pregnancy group (P = ۰.۰۰۱, P = ۰.۰۰۶, respectively). Conclusion: In intact tubal pregnancies managed with medical treatment, serial measurements of CA-۱۲۵ could be a supplementary test for an early diagnosis of tubal rupture.

Keywords:

CA-۱۲۵ antigen , Tubal pregnancy