Squid ink polysaccharide reduces cyclophosphamide-induced testicular damage via Nrf۲/ARE activation pathway in mice
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 18، Issue: 8
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-18-8_014
تاریخ نمایه سازی: 23 اسفند 1402
Abstract:
Objective(s):Cyclophosphamide (CP) toxicity on testis was hampered by squid ink polysaccharide (SIP) via restoration of antioxidant ability in our previous investigations. This study investigated roles of Nrf۲/ARE signal pathway in testis of treated mice. Materials and Methods: Male Kunming mice were employed to undergo treatment with SIP and/or CP. Protein levels of Nrf۲, keap-۱, histone deacetylase ۲ (HDAC۲), quinone oxidoreductase ۱ (NQO-۱), and heme oxygenase ۱ (HO-۱) and phosphorylation level of protein kinase C (PKC) in testis were evaluated by Western blotting. Results: Data showed that SIP elevated expressions of NQO-۱ and HO-۱ genes, two downstream target molecules of Nrf۲, via activating Nrf۲ to play preventive roles on CP-treated testis, and further discovered that upstream regulators of Nrf۲, keap-۱, HDAC۲, and PKC, were concerned with the regulation of Nrf۲. Conclusion: These results suggest that SIP could effectively weaken CP-associated testicular damage via Nrf۲/ARE signal pathway.
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Authors
Xiaoyan Le
College of Science, Guangdong Ocean University, Zhanjiang, China
Ping Luo
College of Science, Guangdong Ocean University, Zhanjiang, China
Yipeng Gu
College of Science, Guangdong Ocean University, Zhanjiang, China
Yexing Tao
College of Science, Guangdong Ocean University, Zhanjiang, China
Huazhong Liu
College of Science, Guangdong Ocean University, Zhanjiang, China
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