Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With Depression
Publish place: Caspian Journal of Neurological Sciences، Vol: 10، Issue: 2
Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_CJNS-10-2_002
تاریخ نمایه سازی: 28 اسفند 1402
Abstract:
Background: Depression is a serious mental illness with symptoms such as worry, disturbed sleep and appetite, lack of interest or pleasure, and persistent sorrow.
Objectives: This study aims to assess the effect of fluvoxamine (FLX) on behavioral and electrophysiological alterations of the posterior cingulate cortex (PCC) and the hippocampus in rats with depression.
Materials & Methods: Thirty-two albino rats (weighing ۲۵۰–۳۰۰ g) were divided into four groups; control (sham), chronic mild stress (CMS), FLX, and CMS+FLX. The CMS was induced by applying different stressors for ۳ weeks. Intraperitoneal injection of FLX (۲۵ mg/Kg) was performed daily for ۱۴ days in the treatment group. Depressive-like behaviors were assessed, and local field potentials (LFP) from the hippocampus and the PCC were recorded.
Results: FLX effectively reduced depressive-like behaviors in rats with CMS (P≤۰.۰۵). Additionally, depression-induced alterations in LFP were observed in the hippocampus and the PCC. Depression reduced the power of delta and theta bands and increased the hippocampal low-gamma band power (P≤۰.۰۵). In the PCC, depression increased the power of delta and low-gamma bands and reduced the power of the alpha band (P≤۰.۰۵).
Conclusion: FLX reduce depression-like behaviors in the animal model, possibly through affecting electrophysiological activity of the hippocampus and the PCC.
Keywords:
Depression , Hippocampus , Posterior cingulate cortex , Fluvoxamine , Local field potential recording
Authors
Mahsa Rahimi
School of Biology, Damghan University, Damghan, Iran.
Iran Goudarzi
School of Biology, Damghan University, Damghan, Iran.
Kambiz Rohampour
Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.