Water as a green solvent for fast and efficient synthesis of ۱,۵-benzodiazepines at room temperature by using Water-Tolerant Sulfonic Acid Nanoreactor Based on Tunable Ordered Porous Silica

A rapid and new green synthesis of ۱,۵-Benzodiazepines is reported. The title compounds were prepared by the reaction of different ۱,۲-phenylenediamines and ketones in the presence of ZrOCl۲.۸H۲O on montmorillonite K۱۰ and MCM-۴۱-SO۳H as a nanocatalyst in water. These methods are simple, effective, better yield and environmentally friendly. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Keywords:

ZrOCl۲.۸H۲O on Montmorillonite K۱۰ , MCM-۴۱-SO۳H , heterogeneous catalyst , ۱ , ۵-benzodiazepines