Comparative investigation of the antibacterial effect of the leaf and stem extracts of thePassiflora caerulea by broth microdilution method

Introduction: Today, the use of medicinal plants with the aim of improving respiratoryproblems, treating infections, reducing the side effects of synthetic-chemical compounds andbacterial resistance to antibiotics has become very important. Passionflower (Passifloracaerulea L.) is a valuable medicinal plant and has potential antibacterial compounds. Thephenolic compounds present in Passiflora caerulea have a very important role in inhibitingthe growth of bacteria. These compounds are a good alternative to chemical antimicrobialcompounds. The present study was conducted with the aim of comparing the antimicrobialeffects of the extracts of the leaves and stems of the P. caerulea against human pathogens.Methods: The antibacterial properties of the leaf and stem extracts of the P. caerulea wastested against four human pathogenic bacteria, Pseudomonas aeruginosa, Escherichia coli,Staphylococcus aureus and Streptococcus pyogenes, by broth microdilution method.Minimum Inhibitory concentration (MIC) and Minimum Bactericidal concentration (MBC)were measured to evaluate the antibacterial effects of P. Caerulea extracts. Results: Theanalyzed results showed that the ethanol extract of the leaf compared to the stem extract hasthe highest growth inhibition rate against the tested bacterial species. Conclusion: Therefore,the results of the study can help as a new strategy for the development of new drugs againstpathogenic microbes and progress in the future of the pharmaceutical industry.

Keywords:

Passiflora caerulea L. , Antibacterial , Microdilution broth , MIC , MBC