Hydrogel Based on Alginate-Polyethylene Glycol Polymer Containing Scrophularia striata Extract Nano-Liposomes is an Excellent Nano-Phyto-Extract in Wound Healing; a Geometric and Pathological Study
Publish place: Iranian Journal of Veterinary Surgery، Vol: 18، Issue: 1
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJVS-18-1_007
تاریخ نمایه سازی: 8 خرداد 1403
Abstract:
Due to the anti-inflammatory and antioxidant properties of Scrophularia striata, it is used to heal wounds. Today, hydrogel based on alginate-polyethylene glycol polymer is mainly used due to its drug delivery properties and create of suitable conditions for wound healing. In this study, we tried to investigate the effect of hydrogel based on alginate-polyethylene glycol polymer containing Scrophularia striata extract nanoliposomes on wound healing in rat animal models. Field emission scanning electron microscopy and dynamic light scattering were used to examine nanoliposome and hydrogel. ۱۲۶ Wistar albino rats were randomly divided into ۷ groups (۱۸ rats/group). The rats were anesthetized and their dorsum shaved, a burn wound was created with a cylindrical copper at ۱۰۰° C. Rats' wounds were treated with hydrogel Scrophularia striata extract and on the ۵th, ۱۰th, and ۱۵th days, histopathological evaluation, macroscopic features and wound healing were evaluated and analyzed in different groups. The structure of nanoliposomes was uniform and the size was ۸۰-۱۱۰ nm. Also, the size of the hydrogel was ۳۲۰ nm with nanometric size and spherical morphology. Histopathological evaluation, wound area and wound contraction confirmed that the treatment group had a significant difference from other groups and the effect was almost similar to that of zinc oxide. This study showed that alginate-polyethylene glycol polymer containing Scrophularia striata extract caused wound contraction, and reduced wound area, and can be used for wound healing.
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Authors
Hamid Reza Siahkouhi
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Mohammad Mahdi Molaei
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Ehsanollah Sakhaee
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Reza Kheirandish
Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Pourya Mohammadi
Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, Iran.
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