Effect of Cinnamon Nanoparticles in Presence of HAMLET on the Healing of Wounds Infected with Pseudomonas aeruginosa: An Animal Model Study
Publish place: Iranian Journal of Veterinary Surgery، Vol: 17، Issue: 2
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJVS-17-2_006
تاریخ نمایه سازی: 8 خرداد 1403
Abstract:
The objective was to evaluate the ability of cinnamon nanoparticles (CNPs) in the healing of wounds with Pseudomonas aeruginosa (PAE) infection as well as HAMLET sensitization in rats. Fifty healthy male Wistar rats were used in this study. The rats were divided into ۵ groups (n = ۱۰), randomly. In the NORMAL group, no infected wounds were treated with a sterile solution of saline ۰.۹% (۰.۱ ml). In the PAE group, the wounds with Pseudomonas aeruginosa infection were only treated with a sterile solution of saline ۰.۹% (۰.۱ ml). In the PAE-HMLT group, HAMLET (۱۰۰ µg) was used to treat infected wounds. In the PAE-CNM group, ۱ mg/ml CNPs (۰.۱ ml) were applied topically to treat PAE-infected wounds. In the PAE-HMLT-CNM group, HAMLET (۱۰۰ µg) and ۱ mg/ml CNPs (۰.۱ ml) were applied topically to treat PAE-infected wounds. Microbiological examination, planimetric and biochemical showed a significant difference between rats in the PAE-HMT-CNM group in comparison with other groups (p < ۰.۰۵). In conclusion, CNPs could offer the potential to pay more attention to this harmless and easily available agent to be topically applied in wounds with infection.
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Authors
Ali Ramezani
Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran
Alireza Najafpour
Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.
Mohammad Reza Farahpour
Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.
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