The Healing Potential of Oleaster Leave Water Soluble Extract on Experimental Skin Wounds in the Rat

Objective- To evaluate the healing potential of oleaster leave water soluble extract on skin wounds. Design- Experimental study. Animals- ۳۰ male Sprague-Dawley rats, randomly assigned in two equal groups. Procedures- Under general anesthesia, and following surgical preparation, two uniform skin defects were made by ۷mm skin punch. The water soluble extract was then applied on half of the wounds for ۷ days. The animals were sacrificed on day ۸ and histopathological and biomechanical samples were taken. Wound planimetry was also performed. Results-  All the evaluated parameters in histopathological and biomechanical studies were significantly superior in treatment group in comparison with the control one. The surface area of the treatment wounds were also significantly less than the control wounds. Conclusion and Clinical Relevance- This study showed that oleaster leave extract has a pro-healing effect on the experimental skin wounds and it can be considered as an available herbal preparation with reasonable cost.

Keywords:

Oleaster leave extract , wound healing , histopathology , Biomechanics , Rat