Quantitative and Qualitative Scintigraphic Measurement of Renal Function in Persian Cat Using ۹۹mTechnetium Ethylenedicysteine and ۹۹mTechnetium Diethylenetriaminepentaacetic

Objective- To consider the use of renal scintigraphic evaluation of kidney function in Persian cat and make a comparison between ۹۹mTechnetium ethylenedicysteine and ۹۹mTechnetium diethylenetriaminepentaacetic in renal scintigraphy.Design- Descriptive studyAnimals- ۶ male healthy adult Persian cats - no clinical sign of renal disorders and prior to presentation.Procedure- The scintigraphy of right and left kidney using Gamma camera (Piker Model) and ۹۹mTc-EC and ۹۹mTc-DTPA as radiopharmaceuticals. Peak activity percentage (% PA), peak time (Tmax), half emptying-time (T۱/۲), total and individual GFR and flow and function time activity curves (TACs) are the determined parameters in this evaluation.Results- % PA, Tmax and T۱/۲ in left and right kidney for ۹۹mTc-EC and ۹۹mTc-DTPA respectively, were ۴۹/۸۶ %, ۵۰/۱ %, ۱۱/۳ min, ۱۱/۵ min, ۴/۴ min, ۴/۶ min and ۵۱/۲۷ %, ۴۹/۰۵ %, ۷/۷ min, ۸/۳ min, ۳ min, ۳/۴۳ min.Moreover the quantities of total and individual GFR for left and right kidney measured by ۹۹mTc-DTPA measured by modified Gates technique respectively, were ۱۲۵/۶۹ ml/min, ۶۴/۴۲ml/min (۵۱/۲۶ %), ۶۱/۲۴ml/min (۴۸/۷۳ %) and were in normal range defined by Gates technique.Conclusion and Clinical Relevance- normal indices obtained for listed parameters and total and individual GFR quantities can play a major role in order to diagnose kidney disorder or function deterioration and can be a background and specialized knowledge conducive to future studies.Also comparison of two radiopharmaceuticals ۹۹mTc-EC and ۹۹mTc-DTPA showed that ۹۹mTc-DTPA scintigraphy has the superiority to assess the quantities of total and individual GFR so we can use ۹۹mTc-DTPA to evaluate Glomerular filtration rate in both kidneys.

Keywords:

scintigraphy , Kidney , Cat