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Comprehensive and updated review on anti-oxidant effects of Nigella sativa and its constituent, thymoquinone, in various disorders

Publish place: Iranian Journal of Basic Medical Sciences، Vol: 27، Issue: 8
Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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لینک ثابت به این Paper:
https://civilica.com/doc/1993189

شناسه ملی سند علمی:

JR_IJBMS-27-8_001

تاریخ نمایه سازی: 16 خرداد 1403

Abstract:

Several pharmacological effects were described for Nigella sativa (N. sativa) seed and it has been used traditionally to treat various diseases. In this review article, the updated and comprehensive anti-oxidant effects of N. sativa and its main constituent, thymoquinone (TQ), on various disorders are described. The relevant articles were retrieved through PubMed, Science Direct, and Scopus up to December ۳۱, ۲۰۲۳. Various extracts and essential oils of N. sativa showed anti-oxidant effects on cardiovascular, endocrine, gastrointestinal and liver, neurologic, respiratory, and urogenital diseases by decreasing and increasing various oxidant and anti-oxidant marketers, respectively. The main constituent of the plant, TQ, also showed similar anti-oxidant effects as the plant itself. The anti-oxidant effects of different extracts and essential oils of N. sativa were demonstrated in various studies which were perhaps due to the main constituent of the plant, TQ. The findings of this review article suggest the possible therapeutic effect of N. sativa and TQ in oxidative stress disorders.

Keywords:

Anti-Oxidants , Essential oil , Plant extracts , Nigella Sativa , Oxidative stress , Thymoquinone

Authors

Mohammad Reza Aslani

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Saeideh Saadat

Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Mohammad Hossein Boskabady

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

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