Chemical Composition, Antioxidant Properties, and Antimicrobial Activity of Ferula assa-foetida L. Essential Oil against Pathogenic Bacteria
Publish place: Chemical Methodologies، Vol: 8، Issue: 5
Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
View: 31
This Paper With 22 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_CHM-8-5_004
تاریخ نمایه سازی: 19 خرداد 1403
Abstract:
Ferula assa-foetida L. (Asafoetida) a medicinal plant with antimicrobial and antioxidant properties, is crucial in the food and pharmaceutical industries. Ferula essential oils (EOs), rich in ferulic acid, flavonoids, alkaloids, and glycosides compositions, may offer a potential solution to antibiotic resistance. The aim of this work is to investigate the components of Ferula chemical essential oil (EO) and its antioxidant and antimicrobial properties in different habitats of Iran (Tabas, Yazd, Neishabur, and Kerman). Gas Chromatography-Mass Spectrometry (GC-MS) analysis was performed to determine the composition of the essential oils from the four different sources. The antimicrobial activity, the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC) of the essential oils against both Gram-positive and Gram-negative pathogenic bacteria were evaluated using the broth microdilution method and the well diffusion test. Likewise, the antioxidant properties of the essential oils were examined using the DPPH radical scavenging method. GC-MS analysis identified the major components of the essential oils, with the Nishabur EO having the highest percentage of components. The Kerman EO had the lowest inhibitory concentration against Escherichia coli, at ۶.۲۵ mg/ml, while the Yazd EO demonstrated the highest inhibitory concentration against Staphylococcus aureus, at a minimum inhibitory concentration of ۵۰ mg/ml. Yazd EO showed the strongest antimicrobial activity, particularly against Gram-positive bacteria, with a halo diameter of ۲۲.۵ mm. In contrast, the Kerman EO showed the least amount of antimicrobial activity against Escherichia coli, with a halo diameter of ۱۱.۵ mm. Kerman EO had the highest antioxidant activity, with ۹۳.۹۳۹۳%. The Ferula EO has the ability to inhibit DPPH radicals and demonstrated activity against both Gram-positive and Gram-negative bacteria, making it a strong antioxidant and natural preservative in the pharmaceutical industry.
Keywords:
Authors
Tahereh Sangchooli
Department of Biology, Naghshejahan Institute of Higher Education, Baharestan, Isfahan, Iran
Sobhan Aboulhassanzadeh
School of Biotechnology Faculty of Science and Health, Dublin City University, Dublin, Ireland
Hamed Aghazadeh
Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Sciences, Tabriz, Iran
Marzieh Paeizi
Department of Biology, Naghshejahan Institute of Higher Education, Baharestan, Isfahan, Iran
Dariush Shokri
Department of Microbiology, Nobel Laboratory, Isfahan, Iran
Maryam Malekzadeh
Department of Chemistry, Payame Noor University, Tehran, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :