Antidiabetic and antioxidant effects of sage tea, Salvia officinalis in male rats exposed to hydrogen peroxide as a source of reactive oxygen species

The antidiabetic and antioxidant effects of Salvia officinalis (sage tea) were studied in ۲۰ mature male rats for ۴۲ days. The rats were divided into four equal groups and given the following treatments: group one as a control group (C), rats only received tap water; group two (T۱) received ۰.۵% H۲O۲ as a source of reactive oxygen species (ROS); group three (T۲) received sage tea as ۲ mg sage in ۱۵۰ mL boiling water (ad libitum); and group four (T۳) received ۴۰۰ IU/Kg BW/day vitamin E by oral intubation along with ۰.۵% H۲O۲. In order to determine serum glucose levels, blood samples were taken directly from the heart after the end of the experiment. Rats were slaughtered, and pancreas samples were collected for patho-histological analysis. The serum glucose levels in the sage tea with the H۲O۲ group (T۲) and T۳ as compared to the second group (T۱) showed a significant decrease (p ˂ ۰.۰۵). Histological examination revealed significant recovery of the pancreatic tissues especially islets of Langerhans in sage tea and vitamin E rats (T۳). This investigation suggests the antidiabetic effect of sage tea for H۲O۲- induced diabetic rats mediated by their effect as antioxidants.

Keywords:

Salvia officinalis , Hydrogen peroxide , Vitamin E , Type ۲ diabetes mellitus , Rat