The Study Examined the Effectiveness of a Nickel (II) Complex Containing ۵-Acetyl-N-(adamantan-۲-yl) Thiophene-۲-Carboxamide as a Derivative for the Drug Isoniazid in Relation to Bacterial, Cancer and Tuberculosis Activities

Isoniazid is identified as isonicotinylhydrazide (INH) and its derivatives comprising N-containing heterocyclic compounds encompass gained importance in therapeutic chemistry due to their assorted natal bustle such as opposed to mycobacteria, antibacterial, antivirus, antifungal, anti-tumor, and analgesic activities. This complex involves of two isoniazid molecules (INH), six hydrated molecules, and two perchlorate chlorates for each metal center (C۱۲H۲۶N۶Cl۲O۱۶Ni). Nickel (II) is two-component coordinated by two INH molecules via hydrazide groups (N and O) and two other isoniazids via an aromatic nitrogen atom into the nickel (II) coordination sphere. Tuberculosis is a serious infection and one of the drugs used to prevent and treat its isoniazid (INH). A current study examined the method of accomplishment of isoniazid (INH), an important chemotheraphatic agent of tuberculosis, and also estimated dead set against-mycobacterial potential of isoniazid derivatives. We interested to compile intelligences on various isoniazid derivatives with described various biological activities such as opposed to mycobacterial, bacterial, fungal and viral activity. This study investigates the synthesis and characterization of a novel nickel (II) complex derived from ۵-acetyl-N-(adamantan-۲-yl) thiophene-۲-carboxamide, aimed at enhancing the efficacy of isoniazid in combating bacterial infections, cancer, and tuberculosis. The complex was synthesized using a facile method and characterized through various analytical techniques, including spectroscopic and elemental analyses. Results revealed that the nickel (II) complex exhibited enhanced efficacy against bacterial strains, cancer cells and Mycobacterium tuberculosis, suggesting its potential as a multifunctional therapeutic agent.

Keywords:

Pharmacodynamics , antiretroviral (ARV) , drug-resistant strains (DR) , Antibacterial Activity , anticancer activity