Synthesis, Characterization, and Application of CoFe₂O₄@SiO₂@CPTES@Melamine Nanoparticles as a Magnetic Catalyst for the Synthesis of Pyrazole Derivatives

In this work, an efficient procedure for the synthesis of pyrazole derivatives via a one-pot multi-component reaction of phenyl hydrazine, malanonitrile, and various aromatic aldehydes using CoFe۲O۴@SiO۲@CPTES@Melamine as a magnetic nanocatalyst in water under room temperature conditions is reported. This nanocatalyst was synthesized in several steps and identified by various techniques including Fourier-transform infrared (FT-IR), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM) techniques. The advantages of using this magnetic nanocatalyst in this research include easy synthesis, efficiency, non-toxicity, high-efficiency product production, short reaction time, and reusability.

Keywords:

۵-Amino-۱H-pyrazole-۴-carbonitrile , Phenylhydrazine , Malononitrile benzaldehyde