Anterior-segment optical coherence tomography for tacrolimus therapy response monitoring of vernal keratoconjunctivitis

Abstract Background: Vernal keratoconjunctivitis (VKC), a chronic bilateral eye disease, is a severe form of allergic conjunctivitis. Anterior-segment optical coherence tomography (AS-OCT) is a rapid, noninvasive, in vivo visualization modality for the anterior segment structures that has been used in diagnosing and staging diseases and assessing the treatment efficacy. We used anterior-segment optical coherence tomography (AS-OCT) to monitor the efficacy of the tacrolimus eye ointment in managing VKC. Methods: In this prospective follow-up study, we included patients with active symptomatic VKC. All patients were treated with the ۰.۰۳% tacrolimus ophthalmic ointment twice daily for ۲ months and then once daily for ۱ month. All patients underwent AS-OCT before and ۳ months after treatment as an objective method to assess the treatment efficacy. Results: We included ۲۰ eyes of ten patients (nine men and one woman) with active symptomatic VKC. The mean age was ۱۷.۳ (range: ۱۱ – ۳۶) years, with nine patients having a palpebral type and one patient having a mixed type of VKC. Substantial flattening and reduction in the papilla size were observed in all patients at the post-treatment follow-up. AS-OCT measurements revealed significant reductions in the vertical, horizontal, and total diameters of the palpebral papillae and limbal conjunctival thickness after ۳ months of treatment compared to baseline measurements (all P < ۰.۰۰۱). No serious adverse effects attributable to tacrolimus administration were observed in the study period. Conclusions: AS-OCT is a suitable objective method for evaluating the treatment efficacy of the ۰.۰۳% tacrolimus eye ointment in patients with VKC. Future large-scale studies including a wide range of age groups with longer follow-up periods and AS-OCT monitoring at multiple post-treatment visits are required to confirm our preliminary results. Moreover, the diagnostic accuracy of AS-OCT in monitoring patients with active VKC should be tested in comparison with objective scoring by an experienced corneal fellowship. Keywords: tacrolimus anhydrous vernal keratoconjunctivitis optical coherence tomography papillae side effects palpebral conjunctiva bulbar conjunctiva