Does recreational drug use influence survival and morbidity associated with laryngeal cancer
Publish place: Addiction and Health، Vol: 14، Issue: 2
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_AHJK-14-2_006
تاریخ نمایه سازی: 9 مرداد 1403
Abstract:
Background: The use of opioids is considered a risk factor for laryngeal cancer. A retrospective study was performed to explore the relationship between recreational drug exposure and laryngeal cancer.Methods: Patients diagnosed between the ۱st of January ۲۰۱۳ and the ۳۱st of December ۲۰۱۷ using ICD-۱۰ CD-۳۲ coding were identified from the Head and Neck Multidisciplinary Team database. We divided the study population into two cohorts (RD and non-RD) and compared the demographics, morbidity, and outcomes of these two populations. In addition, we performed case-matched analysis to control for potential confounding factors including gender, alcohol use and cigarette smoking.Findings: ۳۲۹ patients in Glasgow, Scotland were included with a mean age of ۶۴.۹۶ ± ۱۰.۹۴ and a follow-up of ۲۴ ± ۱۳.۹۱ months. Of these, ۳۹ reported recreational drug use (RD). RD was associated with younger age (۵۳.۰ vs. ۶۶.۶, p<۰.۰۰۱) at diagnosis with laryngeal cancer. A greater proportion of tumours occurred in the supraglottic subsite (p=۰.۰۴۱). Furthermore, these patients were more likely to undergo tracheostomy (RR=۲.۵۰, ۹۵% CI: ۱.۴۱-۴.۴۴, p=۰.۰۰۸) and laryngectomy (RR=۲.۲۵, ۹۵% CI: ۱.۵۷-۳.۲۱, p<۰.۰۰۱). Recreational drug users were more likely to require enteral feeding support (RR= ۱.۴۴, ۹۵% CI: ۱.۱۳-۱.۸۴, p=۰.۰۲) during oncological treatment. No survival differences were noted at ۱, ۲, or ۳-years (plog-rank=۰.۸۳). Case matched analysis correcting for smoking, alcohol and gender confirmed that recreational drug users were younger at diagnosis with a predilection for the supraglottic subsite.Conclusion: Recreational drug use is associated with an increased burden of disease and morbidity in laryngeal cancer. We suggest that clinicians view recreational drug exposure as a red flag in those with suspected laryngeal cancer regardless of patient age.
Keywords:
Head and Neck neoplasms , Laryngeal neoplasms , Substance-related disorders , Analgesics , Opioid , Illicit drugs
Authors
Niall Woodley
ENT Department, Queen Elizabeth University Hospital, Glasgow, G۵۱ ۴TF
Mohd Afiq Mohd Slim
ENT Department, Queen Elizabeth University Hospital, Glasgow, G۵۱ ۴TF
Trung Ton
ENT Department, Queen Elizabeth University Hospital, Glasgow, G۵۱ ۴TF
Jenny Montgomery
ENT Department, Queen Elizabeth University Hospital, Glasgow, G۵۱ ۴TF
Catriona Douglas
ENT Department, Queen Elizabeth University Hospital, Glasgow, G۵۱ ۴TF