Comparing Triptorelin and Buserelin in Ovarian Stimulation Outcomes in Women Undergoing ICSI/ET

Background & Objective: There is a need for studies to find the best method for inhibiting the pituitary gland in in vitro fertilization (IVF) cycles. This study was conducted with the aim of comparing triptorelin ۱% and buserelin in women undergoing intracytoplasmic sperm injection/ embryo transfer (ICSI/ET).Materials & Methods: The present study was a randomized single-blind clinical trial to compare the short-acting triptorelin and buserelin in ovarian response. The patients are divided into two groups A and B based on random allocation and ۶۷ people in each group were included in the study. To evaluate the basic level of hormones, the FSH, LH, and estradiol levels were checked. In addition, AMH level on the third day of the cycle, age, body mass index (BMI), duration of infertility (years), frequency of using IVF/ICSI based on each cycle, duration of ovarian stimulation (days), and average dose gonadotropin consumption (the ampoule dose per unit) was recorded.Results: The mean dose of gonadotropin in the group treated with triptorelin (۳۱۸۱.۲۹±۷۱۰.۱۳) was higher than in the group treated with buserelin (۲۴۳۳.۸۷±۹۳۶.۵۲) (P-value<۰.۰۰۱). The frequency of positive OHSS in the group treated with buserelin was ۱۴ (۲۲.۶%), which was higher than in the group treated with triptorelin ۰ (۰.۰%) (P-value<۰.۰۰۱).Conclusion: In the findings of our study, no significant difference was observed in the progesterone level on the day of trigger injection in the comparison of two agonists, and both agonists were successful in preventing LH surge.

Keywords:

Triptorelin , Buserelin , In vitro fertilization , infertility